Research advances in DNA adducts: their formation, diagnosis and pollution-exposure indication
Wang, M'e.; Zhou, Q.
Ying Yong Sheng Tai Xue Bao 15(10): 1983-1987
2004
ISSN/ISBN: 1001-9332 PMID: 15624849 Document Number: 567488
With the cognitive penetration of ecotoxicological effects into a molecular level, more attention has been paid to the research on DNA adducts. This paper analyzed toxic mechanisms and formative processes of DNA adducts, and introduced in brief their diagnostic methods, including chromatogram-mass spectrum method, 32P post-labeling method, immunology method and fluorescence method. The pollution-exposure indication of DNA adducts was expounded as an effective molecular biomarker, and thus, DNA adducts could be used by ecotoxicologists as a good caution signal in forecasting hazardous effects of pollutants.