Redox status in HIV+ patients under HAART
Flourié, F.; Arab, K.; Gagnieu, M.C.; Tardy, J.C.; Jeanblanc, F.; Livrozet, J.M.; Steghens, J.P.
Annales de Biologie Clinique 62(6): 713-715
2004
ISSN/ISBN: 0003-3898 PMID: 15563432 Document Number: 567481
Oxidative stress decreases immune defences and is also suggested to participate in the activation of HIV virus replication. That is why we decided to explore some biomarkers of oxidative stress (reduced glutathione, lipoperoxides, true malondialdehyde and vitamin C) in 20 HIV positive patients whose HIV replication was determined by measurement of RNA viral load. Reduced glutathione is decreased in HIV positive patients, without correlation with the viral load. The patients mean content of lipoperoxides is twice that of controls but with such a large range that there is no statistical difference.