Retroperitoneal fibrosis caused by pergolide in a patient with Parkinson's disease
Bilici, A.; Karadag, B.; Doventas, A.; Erdincler, D.S.; Cetinkaya, S.; Ogut, G.; Tezcan, V.; Beger, T.
Netherlands Journal of Medicine 62(10): 389-392
2004
ISSN/ISBN: 0300-2977 PMID: 15683095 Document Number: 567414
Retroperitoneal fibrosis (RPF) is an uncommon disorder that may cause ureteric obstruction with renal damage. Pergolide, a dopaminergic agonist used in the treatment of Parkinson's disease, has rarely been related to the development of RPF. We report on a 78-year-old woman with Parkinson's disease who presented with hydroureteronephrosis and developed RPF and serosal fibrosis during treatment with pergolide. Following discontinuation of pergolide therapy and placement of a double-J stent, her renal function improved. Inflammatory markers returned to normal limits within two months and the retroperitoneal fibrotic mass became smaller.