Effects of L-dopa and transcranial magnetic stimulation on behavioral reactions in kindled rats
Godlevskiĭ, L.S.; Kobolev, E.V.
Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 89(9): 1078-1084
2003
ISSN/ISBN: 0869-8139 PMID: 14758631 Document Number: 565574
In acute experiment in rats, the chronic epileptogenesis was reproduced in the form of pharmacological kindling induced via repeated picrotoxin administrations (1.0-1.2 mg/kg, intraperitoneally). A reduction of exploratory behavior was shown in the early period of kindling (24 h as of the moment of the last epileptogen administration). The marked alleviation of these disturbances was registered in two weeks from the moment of cessation of kindled irritations. L-DOPA (100 mg/kg, intraperitoneally) and transcranial magnetic stimulation (20 impulses with an induction at the height of their development of 1.5 TI) was followed by the net increasing exploratory, sexual and eating behavior. This is in favour of regarding the activation of dopaminergic system as a mechanism of action of transcranial magnetic stimulation upon kindling-induced behavioral deterioration.