The importance of transmission time in HIV infections and an epidemiological prospective follow-up study for 1 year in the Marmara Region of Turkey

Celik, D.Gozde.; Yuksel, P.; Aslan, M.; Saribas, S.; Baltali, N.Dirik.; Abdelkareem, A.; Ziver, T.; Nazlican, O.; Gencer, S.; Celikkol, Eğan.; Bahar, H.; Kocazeybek, B.; Celik, D.Gozde; Yuksel, P; Aslan, M; Saribas, S; Baltali, N.Dirik; Abdelkareem, A; Ziver, T; Nazlican, O; Gencer, S; Celikkol, Egan; Bahar, H; Kocazeybek, B

doi:10.1016/j.transci.2012.03.003

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The importance of transmission time in HIV infections and an epidemiological prospective follow-up study for 1 year in the Marmara Region of Turkey

Celik, D.Gozde.; Yuksel, P.; Aslan, M.; Saribas, S.; Baltali, N.Dirik.; Abdelkareem, A.; Ziver, T.; Nazlican, O.; Gencer, S.; Celikkol, Eğan.; Bahar, H.; Kocazeybek, B.

Transfusion and Apheresis Science Official Journal of the World Apheresis Association Official Journal of the European Society for Haemapheresis 47(1): 3-7

2012

ISSN/ISBN: 1473-0502

PMID: 22483628

DOI: 10.1016/j.transci.2012.03.003

Document Number: 565042

It is important to detect recent and new HIV/1 infections and to take preventative measures in order to prevent rapid disease progression in AIDS and to decrease the incidence of infection. We aimed to detect long standing or recent HIV infections by determining transmission times for the cases in which first-time HIV/1 seropositivity were detected. The serum samples of 323 cases which were found to be seropositive by ELISA and Western-blotting were included in this study. The discrimination between long-term and recent HIV/1 infection was made by determining transmission-time with the Aware BED-EIA, HIV-1 incidence test (IgG capture HIV-EIA) tests. Ninety-six healthy blood donors who did not have a positive anti-HIV test and a chronic infectious disease for at least 1year were included in this study as a negative healthy control group. In the discrimination of long-term and recent HIV/1 infections, only in vitro ODn values were used. The cases with normalized optical density (OD) (ODspecimen/ODcalibrator)<.8 by commercial kit were accepted as recent HIV infection (155days history or seroconversion less than 6months). The cases with ODn >1.2 were accepted as long-term HIV/1 infections (more than 155days history or more than 6months). The cases with ODn between .8 and 1.2 were accepted as additional tests needed cases. We detected recent HIV/1 infections (<6months) in 6 (18.5%) out of 323 cases and long-term HIV/1 infections (>6months) in 263 (81.5%) out of 323 cases. The most frequently encountered transmission route in long-term and recent HIV/1 infections was heterosexual sexual intercourse as 54 (5%) and 257 (97%), respectively. 63.3% of newly infected patients were married females and 65.3% of recently infected patients were males. In conclusion, the detection of the high ratio of long-term HIV/1 infection cases (81.5%) compared to recent infections (18.5%) suggested to us, that the long standing cases may have some activities related with transmission of HIV/1 in the past. The detection of higher HIV/1-infections in individuals which had heterosexual sex and also in married males suggested that this situation poses a very great threat for the health of society.

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The importance of transmission time in HIV infections and an epidemiological prospective follow-up study for 1 year in the Marmara Region of Turkey

The importance of transmission time in HIV infections and an epidemiological prospective follow-up study for 1 year in the Marmara Region of Turkey

Celik, D.Gozde.; Yuksel, P.; Aslan, M.; Saribas, S.; Baltali, N.Dirik.; Abdelkareem, A.; Ziver, T.; Nazlican, O.; Gencer, S.; Celikkol, Eğan.; Bahar, H.; Kocazeybek, B.

Transfusion and Apheresis Science Official Journal of the World Apheresis Association Official Journal of the European Society for Haemapheresis 47(1): 3-7

2012

Document emailed within 0-6 h

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