Mast cell number as an indicator of angiogenesis in autotransplanted tissue
Maĭborodin, I.V.; Domnikov, A.V.; Kovalevskiĭ, K.P.
Morfologiia 124(6): 66-70
2003
ISSN/ISBN: 1026-3543 PMID: 14994594 Document Number: 564847
Using the methods of light microscopy, mast cell (MC) distribution was studied and their number was counted in the dermis of autotransplanted vascularized tissue complexes at different time intervals following the operation. The number of MC in the dermis during the process of angiogenesis was closely connected with the number of blood vessels as evidenced by the direct correlation between these two parameters 2-3 weeks, 2-4 months and 5-8 months after the transplantation. MC seem to participate in the control of blood and lymph vessel formation as witnessed by high MC concentration close to the formed vessels and low MC concentration at a distance from them 2-4 and 5-8 months following the transplantation. It is suggested that the data on MC number may be helpful in prognosis of angiogenesis intensity in tissues, time intervals of edema reduction after organ or tissue transplantation, outcome of lymphedema treatment, velocity of tumor metastasis spread.