New approaches in managing bipolar depression
Keck, P.E.; McElroy, S.L.
Journal of Clinical Psychiatry 64(Suppl 1): 13-18
2003
ISSN/ISBN: 0160-6689 PMID: 12625800 Document Number: 564580
Historically, the pharmacologic treatment of bipolar depression has not been well studied. New data are beginning to emerge regarding the efficacy of new medications and the use of combinations of mood stabilizers and antidepressants in acute and long-term treatment of bipolar depression. We reviewed data from recent randomized, controlled trials of mood stabilizers and antidepressants in the treatment of bipolar depression and naturalistic studies examining the risk of switching and depressive relapse with ongoing antidepressant treatment.