Herpes simplex virus type 2 infection as a biomarker for sexual debut among young people in sub-Saharan Africa: a literature review
Bastien, S.; Mason-Jones, A.J.; De Koker, P.; Mmbaga, E.J.; Ross, D.A.; Mathews, C.
International Journal of Std and Aids 23(11): 761-766
2012
ISSN/ISBN: 0956-4624 PMID: 23155093 DOI: 10.1258/ijsa.2012.011433Document Number: 564091
Biological markers are needed in order to provide objective measures to validate self-reported sexual behaviour and interpret prevention trial data. In this review, we evaluated herpes simplex type 2 virus (HSV-2), one of the most prevalent sexually transmitted infections in sub-Saharan Africa as a biological marker of sexual debut. Based on our findings, we do not recommend using HSV-2 as a biomarker for sexual debut due to its low transmission probabilities and the fact that HSV-2 prevalence is not 100% among potential sexual partners. We recommend that the validation of alternative biological measures should be prioritized, and included in future studies and trials of interventions to reduce sexual health risk.