Treatment of non-dopamine-dependent signs in parkinsonian syndromes: evaluation and results
Tardieu, S.; Becker, H.; Micallef, J.; Blin, O.
Revue Neurologique (Paris) 159(5 Part 2): 3s87-3s92
2003
ISSN/ISBN: 0035-3787 PMID: 12773893 Document Number: 563334
With dopaminergic systems, non dopaminergic neurotransmission probably plays a major role in parkinsonian syndromes (Multiple System Atrophy, Progressive Supranuclear Palsy, Pure Autonomic Failure, Cortical basal degeneration, Lewy Body Disease). A better understanding of the pathophysiology of these syndromes led to the developement of molecules that interact with non dopaminergic systems. Thus, freezing, gait and balance disorders, dysautonomia and neuropsychiatric disorders are likely to benefit from specific treatments. However, due to methodological difficulties related to the evaluation of such molecules, controlled trials are rather rare and the results are often partial and sometimes unclear.