Renal dysfunction in workers exposed to arsenic and cadmium
Hong, F.; Jin, T.-y.; Lu, G.-d.; Yin, Z.-y.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 21(6): 432-436
2003
ISSN/ISBN: 1001-9391 PMID: 14761355 Document Number: 563115
To examine the nephrotoxicity induced caused by combined effect of arsenic and cadmium in exposed workers. Urinary cadmium and arsenic were used as the exposure biomarkers of cadmium and arsenic. Urinary beta2-microglobulin (Ubeta2-MG), albumin (UALB) and N-acetyl-beta-D-glucosaminidase (UNAG) were measured as the effective biomarkers of tubular and glomerular dysfunction induced by cadmium and arsenic. The combination of cadmium and arsenic induced more severe renal injury than that caused by either of the chemicals given alone. There were positive correlations and significant dose-effect among the concentrations of urinary cadmium, arsenic and levels of Ubeta2-MG, UALB, UNAG (P<0.05, P<0.01). Cadmium combined with arsenic may have additive effect on renal dysfunction in workers exposed to arsenic and cadmium.