Intracervical release of ST-1435 for contraception

Kurunmäki, H.; Toivonen, J.; Lähteenmäki, P.L.; Luukkainen, T.; Kurunmäki, H; Toivonen, J; Lähteenmäki, P.L; Luukkainen, T

doi:10.1016/0010-7824(84)90015-5

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Intracervical release of ST-1435 for contraception

Kurunmäki, H.; Toivonen, J.; Lähteenmäki, P.L.; Luukkainen, T.

Contraception 29(5): 411-421

1984

ISSN/ISBN: 0010-7824

PMID: 6430641

DOI: 10.1016/0010-7824(84)90015-5

Document Number: 562807

Seven women used an ST-1435-releasing intracervical contraceptive device (ST-ICD), inserted immediately after the cessation of menstrual bleeding. Patterns of bleeding and clinical performance were evaluated and plasma concentrations of ST-1435, estradiol, progesterone and gonadotropins were measured by radioimmunoassays. The results of ten months of treatment are presented. There were no uniform patterns of bleeding. No hormonal side-effects were registered. The plasma concentration of ST-1435 reached 100 pg/ml within two hours after insertion of an ST-ICD. No ovulations occurred during the initial three months of treatment. A rapid decline in the plasma concentrations of ST-1435 was observed; during the tenth month the concentration of ST-1435 was under the sensitivity of the radioimmunoassay of ST-1435. Hence, the release of ST-1435 from Silastic was too rapid for long-acting contraceptive purposes.

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Grignaffini, A.; Soncini, E.; Anfuso, S.; Ronzoni, E. 2004: Dinoprostone: slow release vaginal insert (Propess) and intracervical gel (Prepidil) for the induction of labour with unriped cervix Minerva Ginecologica 56(5): 413-418

Schwartz, J.L. 2001: Release of progestin-only emergency contraception Current Women's Health Reports 1(3): 191-195

Hagenfeldt, K.; Landgren, B.M. 1975: Contraception by intrauterine release of progesterone--effects on endometrial trace elements, enzymes and steroids Journal of Steroid Biochemistry 6(6): 895-898

Rollet, J.; Guerin, J.F.; Czyba, J.C. 1983: La contraception masculine: les différentes possibilités actuelles: essai d'une contraception hormonale associant un progestatif et un androgène - Male contraception: the various possibilities currently available. Trial of a hormonal contraception combining a progestagen with an androgen Revue Francaise de Gynecologie et d'Obstetrique 78(5): 365-371

Intracervical release of ST-1435 for contraception

Kurunmäki, H.; Toivonen, J.; Lähteenmäki, P.L.; Luukkainen, T.

Contraception 29(5): 411-421

1984

Document emailed within 0-6 h

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