Critical review of pathogenetic mechanisms in myelofibrosis with myeloid metaplasia
Martyré, M.-C.
Current Hematology Reports 2(3): 257-263
2003
ISSN/ISBN: 1540-3408 PMID: 12901348 Document Number: 562274
Myelofibrosis with myeloid metaplasia is an uncommon chronic myeloproliferative disorder characterized by extramedullary hematopoiesis associated with varying degrees of bone marrow fibrosis (hematopoiesis is clonal and fibrosis is a polyclonal reactive process). The primary defect in a pluripotent stem cell is still unknown. However, advances have been made during the past few years in the knowledge of the pathogenetic mechanisms in this disorder. This review focuses on current data on the cellular and molecular mechanisms possibly participating in the development of the disease.