A novel marker of multiple drug resistance BCRP
Bogush, T.A.; Pokataev, I.A.; Timofeeva, N.V.; Ozherel'ev, A.S.
Antibiotiki i Khimioterapiia 48(6): 33-41
2003
ISSN/ISBN: 0235-2990 PMID: 14558417 Document Number: 561964
Data on a new marker of multidrug resistance from the group of ABC-transporters--BCRP (breast cancer resistance protein) and in particular the data on the general characteristics of BCRP, spectrum of substrates for this transporter, data on the role of BCRP in human organism, pathways of inhibiting BCRP-dependent transport by pharmacological agents are presented. The data on BCRP expression in human normal tissues and tumor cells are considered in detail. Possible reasons of results inconsistency in evaluation of BCRP expression in different tumors and prognostic significance of BCRP in prediction of sensitivity to chemotherapy and aggressiveness of disease process are discussed.