Changes in sexual behaviour among HIV-infected women in west and east Africa in the first 24 months after delivery
Irungu, E.; Chersich, M.F.; Sanon, C.; Chege, R.; Gaillard, P.; Temmerman, M.; Read, J.S.; Luchters, S.; Dioulasso, B.; Faso, B.; Meda, N.; Fao, P.; Ky-Zerbo, O.; Gouem, C.; Somda, P.; Hien, Hé.; Ouedraogo, P.Elysée.; Kania, D.; Sanou, A.; Kossiwavi, I.Ayassou.; Sanogo, B.; Ouedraogo, M.; Siribie, I.; Valéa, D.; Ouedraogo, S.; Somé, R.; Rouet, Fçois.; Luchters, S.; Reyners, M.; Irungu, E.; Katingima, C.; Mwaura, M.; Ouattara, G.; Mandaliya, K.; Wambua, S.; Thiongo, M.; Nduati, R.; Kose, J.;
Aids 26(8): 997-1007
2012
ISSN/ISBN: 0269-9370 PMID: 22343965 DOI: 10.1097/qad.0b013e3283524ca1Document Number: 561807
Describe changes in sexual behaviour and determinants of unsafe sex among HIV-infected women in the 24 months after delivery. Cohort analysis nested within a prevention of mother-to-child transmission trial in Burkina Faso (n = 339) and Kenya (n = 432). Women were followed during pregnancy and until 12-24 months after delivery. At each visit, structured questionnaires were administered about sexual activity and condom use, and risk-reduction counselling and condoms were provided. At study entry, a median 2 months after HIV testing (interquartile range =1-4), 411/770 (53.4%) of women reported partner disclosure, increasing to 284/392 (71.9%) at the final visit. Although most partners were supportive following disclosure, between 5 and 10% of disclosed women experienced hostile or unsupportive partner responses during follow-up visits. At each visit, about a third of sexually active women reported unsafe sex (unprotected sex with HIV-uninfected or unknown status partner). In multivariable logistic regression, unsafe sex was 1.70-fold more likely in Kenyan than in Burkinabe women [95% confidence interval (95% CI) = 1.14-2.54], and in those with less advanced HIV disease or aged 16-24 years. Compared with women who disclosed their status to partners and others, unsafe sex was over six-fold higher in nondisclosers (95% CI = 3.31-12.11), the effect size reducing with increasing disclosure. HIV-infected women who recently delivered have a high potential for further HIV transmission, especially as HIV discordance is common in Africa. Longitudinal care for women, including positive-prevention interventions, is needed within new services providing antiretroviral prophylaxis during breastfeeding - this repeated interface with services could focus on reducing unsafe sex. Much remains unknown about how to facilitate beneficial disclosure.