Evaluation of the factor V HR2 haplotype as a risk factor for ischemic cerebrovascular disease
Lecumberri, Rón.; Ceberio, I.; Montes, Rón.; López, Mía.Luz.; Alberca, I.; Rocha, E.
Haematologica 88(2): 236-237
2003
ISSN/ISBN: 0390-6078 PMID: 12604422 Document Number: 561090
The HR2 haplotype of the factor V (FV) gene has been identified as a cause of resistance to activated protein C, specially in the presence of FV Leiden. We studied the prevalence of the HR2 haplotype in 115 patients with a first episode of ischemic cerebrovascular disease (CVD) and 115 age- and sex-matched healthy controls. Our results show that the HR2 haplotype is not associated with an increased risk of CVD.