Spectrum of therapeutic efficacy and safety of Lorafen (lorazepam) use for anxiety disorders
Ivanov, S.V.; Il'ina, N.A.; Burlakov, A.V.
Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 103(8): 38-41
2003
ISSN/ISBN: 1997-7298 PMID: 14564776 Document Number: 559953
Presented here, are the results of 4-weeks lorafen monotherapy in 31 in-patients of psychiatric and cardio-surgical clinics divided, respectively, into 2 groups: 16 patients with chronic anxiety disorders and 15--with acute developed before an coronary artery bypass surgery in ischemic heart disease. A dynamics of the patients' state was evaluated with Hamilton Rating Scale for Anxiety and the Hospital Anxiety and Depression Scale. Lorafen proved to be highly effective, with percentage of responders being about 77% (24 patients out of 31). Therapeutically effective dosage was 3.7 +/- 1.1 mg daily for chronic anxiety disorders and 2.1 +/- 0.6 mg--for situation-induced anxiety. Lorafen was shown to be tolerable and safety.