Isoniazid associated, painful, bilateral gynaecomastia
Khanna, P.; Panjabi, C.; Maurya, V.; Shah, A.
Indian Journal of Chest Diseases and Allied Sciences 45(4): 277-279
2003
ISSN/ISBN: 0377-9343 PMID: 12962465 Document Number: 559625
Gynaecomastia is a rarely reported adverse drug reaction due to isoniazid therapy. We describe a 25-year-old, human immunodeficiency virus (HIV)--negative man, who was started on antituberculosis treatment (ATT) with isoniazid (H), rifampicin (R), pyrazinamide (Z) and ethambutol (E) in the combination RHZE for the first two months and RH there on. After four months, while receiving RH, he developed painful bilateral gynaecomastia. ATT had to be stopped because of this adverse drug reaction. Gynaecomastia, however, persisted even after three months of cessation of therapy. A year later, the patient reported complete disappearance of pain and swelling, although right breast continued to appear larger than the left.