Factor V Leiden and myocardial infarction: a case, review of the literature with a meta-analysis
Doix, S.; Mahrousseh, M.; Jolak, M.; Laurent, Y.; Lorenzini, J.L.; Binquet, C.; Zeller, M.; Cottin, Y.; Wolf, J.E.
Annales de Cardiologie et d'Angeiologie 52(3): 143-149
2003
ISSN/ISBN: 0003-3928 PMID: 12938565 Document Number: 559424
Mutation in blood coagulation factor V Leiden is the most frequently genetic polymorphism implied in venous thrombosis. A 57 year old man was hospitalised for acute myocardial infarction (MI). An emergency coronary angiography was performed, and no significant stenosis was observed. The haematologic check-up showed an heterozygous Leiden mutation of factor V. We report all publications about the relation between factor V Leiden and coronary thrombosis, and we performed a meta-analysis. We analysed the relation in general population and in subbgroups, such as, younger and older, and patient with or without coronary stenosis. In global population, the meta-analysis did not found significant association between Factor V Leiden and myocardial infarction (OR=1.25; IC=0.97-1.58). In contrast, in patients less than <55 years old after MI, Factor V Leiden prevalence was significantly higher than in control group (OR=1.48; IC=1.05-2.08). In addition, after MI without significant coronary stenosis Factor V Leiden prevalence was significantly higher than in normal patients (OR=2.84; IC=1.46-5.51). After MI, in patients without significant coronary stenosis, Factor V Leiden prevalence was significantly higher than in patients with significant coronary stenosis (OR=3.26; IC=1.67-6.36). Our study suggests that Factor V Leiden could be search after MI in young subjects and/or without significant stenosis.