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Apoptosis in the cryptorchidism. Role of the FAS protein in it's modulation

Paredes Esteban, R.M.; Ramírez Chamond, R.; Velasco Sánchez, B.; Cuevas, C.; Rodríguez Vargas, J.; Marín Hidalgo, M.; García Ruiz, M.

Cirugia Pediatrica Organo Oficial de la Sociedad Espanola de Cirugia Pediatrica 16(1): 17-19

2003

ISSN/ISBN: 0214-1221
PMID: 12793288
Document Number: 558797
The cellular degeneration, present at the criptorchidism leads to a malfunction in the spermatogenosis and it's due to cellular apoptosis (programed cellular death). This process is turned on and modulated by different ways. One of then is mediated by Ag-Ac reactions and a protein called FAS seems to have an important role in it's modulation. We studied the relation between FAS an the increased apoptosis in undescended testics. Testicular biopsies were done in criptorchid patients during orchidopexy and FAS was measured by immune-techniques. Our results seem to dismiss FAS as a modulation apoptosis factor in the cryptorchidism.

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