The clinical significance of the expression of four cell cycle regulators in breast papillomotosis
Niu, Y.; Liu, T.-j.; Li, Y.; Yu, Y.; Lü, A.-j.; Fu, X.-l.
Zhonghua Yi Xue Za Zhi 83(20): 1769-1773
2003
ISSN/ISBN: 0376-2491 PMID: 14642081 Document Number: 558703
To investigate the clinical significance of the protein expression of 4 cell cycle regulators in papillomatosis of the breast. Immunohistochemistry was used to examine the protein expression of CyclinD1, p16, E2F-1 and Rb in 4 groups (196 cases) with mild papillomatosis (MP), moderate papillomatosis (MoP), serious papillomatosis (SP) and ductal carcinoma in situ (DCIS). There were significant difference of the positive rate and the intensity of CyclinD1, p16, E2F-1 and Rb expression among the groups, respectively (chi(2) were 16.702, 20.742, 40.335, 42.317; 19.120, 29.469, 45.080, 46.920, P < 0.01. Meaning time there were significant difference in the expression of these 4 factors between MoP and SP (P < 0.05). There was significance of E2F-1 or Rb expression between SP and DCIS (P < 0.01), but there was no significance to be found in the expression of CyclinD1 or p16 between the two groups (P > 0.05). Rb was screened as the highest risk factor by Odd Risk Logistic Analysis. CyclinD1, p16, E2F-1 and Rb played the important roles from MP into SP and then DCIS. E2F-1 and Rb can be used as the assistant indicators on the differentiation of SP and DCIS. Rb may be helpful in screening high risk cases from SP or MoP.