The test for nitric oxide metabolites in exhaled air condensate as a method of assessing NO-reactivity of the airways in patients with bronchial asthma
Gel'tser, B.I.; Peteshova, E.E.; Kochetkova, E.A.; Eliseeva, E.V.
Terapevticheskii Arkhiv 75(10): 91-94
2003
ISSN/ISBN: 0040-3660 PMID: 14669617 Document Number: 558280
To estimate airways NO-reactivity in response to their stimulation with fenoterol in different clinical forms of bronchial asthma (BA). The study included 73 patients with BA: mild disease was in 21, moderate--in 24 and severe--in 28 patients. Severe BA patients were divided into two subgroups: with a stable course (n = 15) and unstable course (n = 13). NO-producing function of the airways was estimated by concentration of stable NO-metabolites (mNO)(NO2, NO3) in exhaled air condensate. Spontaneous NO-producing activity of the airways increases and reaches maximum in severe unstable asthma. Fenoterol-stimulated NO-production was minimal in mild BA while the most significant augmentation of mNO was observed in unstable BA. Basal level of mNO and velocity parameters of external respiration function correlated. Estimation of NO-reactivity of the airways in the test with fenoterol with calculation of the index of airways NO-reactivity provides additional information about respiratory system condition in BA patients which may be used in clinical pulmonology.