Top Abstract Purchase Related
Home
>
Node
>
Subnode

Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1)

Wågsäter, D.; Sirsjö, A.; Dimberg, J.

Journal of Experimental and Clinical Cancer Research Cr 22(3): 471-475

2003

ISSN/ISBN: 0392-9078
PMID: 14582708
Document Number: 558089
Accumulated evidence supports that both Id helix-loop-helix proteins and derivatives of vitamin A, retinoids, play a pivotal role in the regulation of cell growth and differentiation. We analyzed the effects of all-trans retinoic acid (atRA) on the gene and protein expression of Id2 in THP-1 cells and found a suppression of the levels of Id2. The down-regulation was abolished towards a constitutively expressed level of Id2 mRNA. The decreased level of Id2 was associated with growth suppression and does support the prevalent conception of the action of Id2 as a stimulator of cell growth.

Document emailed within 1 workday
Secure & encrypted payments

Cornic, M.; Delva, L.; Castaigne, S.; Lefebvre, P.; Balitrand, N.; Degos, L.; Chomienne, C. 1994: In vitro all-trans retinoic acid (ATRA) sensitivity and cellular retinoic acid binding protein (CRABP) levels in relapse leukemic cells after remission induction by ATRA in acute promyelocytic leukemia Leukemia 8(Suppl): S16-S19
Fukutani, H.; Naoe, T.; Ohno, R.; Yoshida, H.; Miyawaki, S.; Shimazaki, C.; Miyake, T.; Nakayama, Y.; Kobayashi, H.; Goto, S. 1995: Isoforms of PML-retinoic acid receptor alpha fused transcripts affect neither clinical features of acute promyelocytic leukemia nor prognosis after treatment with all-trans retinoic acid. the Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho) Leukemia 9(9): 1478-1482
Drach, J.; Lopez-Berestein, G.; McQueen, T.; Andreeff, M.; Mehta, K. 1993: Induction of differentiation in myeloid leukemia cell lines and acute promyelocytic leukemia cells by liposomal all-trans-retinoic acid Cancer Research 53(9): 2100-2104
Wu, Q.; Chen, Z.; Liu, S. 2000: Mechanism of retinoic acid receptor alpha-mediated growth inhibition of gastric cancer cells by all-trans retinoic acid Zhonghua Zhong Liu Za Zhi 22(3): 195-197
Tohda, S.; Curtis, J.E.; McCulloch, E.A.; Minden, M.D. 1992: Comparison of the effects of all-trans and cis-retinoic acid on the blast stem cells of acute myeloblastic leukemia in culture Leukemia 6(7): 656-661
Guo, W.; Wang, H.; Zhao, W.; Zhu, J.; Ju, B.; Wang, X. 2001: Effect of all-trans retinoic acid and arsenic trioxide on tissue factor expression in acute promyelocytic leukemia cells Chinese Medical Journal 114(1): 30-34
Guo, W.; Wang, H.; Zhao, W. 2000: Effects of all-trans retinoic acid and arsenic trioxide on tissue factor expression of acute promyelocytic leukemia cells Zhonghua Yi Xue Za Zhi 80(5): 327-331
Huang, X. 2000: Potentiation of arsenic trioxide-induced apoptosis by retinoic acid in retinoic acid sensitive and resistant HL-60 myeloid leukemia cells Chinese Medical Journal 113(6): 498-501
Asou, N.; Adachi, K.; Tamura, J.; Kanamaru, A.; Kageyama, S.; Hiraoka, A.; Omoto, E.; Akiyama, H.; Ohno, R. 2000: Treatment of acute promyelocytic leukemia with all-trans retinoic acid and chemotherapy--multicenter trial of the Japan Adult Leukemia Study Group (JALSG) Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(8): 1168-1173
Rák, Kálmán. 2002: ATRA (all-trans retinoic acid) in chronic myeloid leukemia? Orvosi Hetilap 143(23): 1449-50; author reply 1450
Huang, M.E. 1988: Treatment of acute promyelocytic leukemia with all-trans retinoic acid Zhonghua Yi Xue Za Zhi 68(3): 131-133; 10
Mano, Y.; Shimizu, T.; Tanuma, S.; Takeda, K. 2000: Synergistic down-regulation of telomerase activity and hTERT mRNA expression by combination of retinoic acid and GM-CSF in human myeloblastic leukemia ML-1 cells Anticancer Research 20(3a): 1649-1652
Ohno, R.; Naoe, T.; Fukutani, H. 1993: Differentiation therapy of acute promyelocytic leukemia with all-trans retinoic acid Gan to Kagaku Ryoho. Cancer and ChemoTherapy 20(8): 1016-1021
Maschan, A.A.; Klebanova, N.G.; Miakova, N.V.; Tiganova, O.A.; Timakov, A.M.; Samochatova, E.V. 1996: Treatment of acute promyelocytic leukemia in children with all-trans-retinoic acid Gematologiia i Transfuziologiia 41(2): 43-45
Wang, Z.Y.; Sun, G.L.; Lu, J.X.; Gu, L.J.; Huang, M.E.; Chen, S.R. 1990: Treatment of acute promyelocytic leukemia with all-trans retinoic acid in China Nouvelle Revue Francaise d'Hematologie 32(1): 34-36
Sun, G.L.; Ouyang, R.R.; Chen, S.J.; Gu, Y.Z.; Huang, L.A.; Lu, J.X.; Wang, Z.Y. 1993: Treatment of acute promyelocytic leukemia with all-trans retinoic acid. a five-year experience Chinese Medical Journal 106(10): 743-748
Dubois, C.; Schlageter, M.H.; de Gentile, A.; Balitrand, N.; Toubert, M.E.; Krawice, I.; Fenaux, P.; Castaigne, S.; Najean, Y.; Degos, L. 1994: Modulation of IL-8, IL-1 beta, and G-CSF secretion by all-trans retinoic acid in acute promyelocytic leukemia Leukemia 8(10): 1750-1757
Tallman, M.S. 1994: All-trans-retinoic acid in acute promyelocytic leukemia and its potential in other hematologic malignancies Seminars in Hematology 31(4 Suppl 5: 38-48
Chen, G.Q.; Shen, Z.X.; Wu, F.; Han, J.Y.; Miao, J.M.; Zhong, H.J.; Li, X.S.; Zhao, J.Q.; Zhu, J.; Fang, Z.W.; Chen, S.J.; Chen, Z.; Wang, Z.Y. 1996: Pharmacokinetics and efficacy of low-dose all-trans retinoic acid in the treatment of acute promyelocytic leukemia Leukemia 10(5): 825-828
Kizaki, K.; Ishii, H.; Horie, S.; Kazama, M. 1994: Thrombomodulin induction by all-trans retinoic acid is independent of HL-60 cells differentiation to neutrophilic cells Thrombosis and Haemostasis 72(4): 573-577