Nitric oxide activity in women with intrauterine growth restriction treated by L-arginine
Karowicz-Bilińska, A.; Kowalska-Koprek, U.; Suzin, J.; Sieroszewski, P.
Ginekologia Polska 74(8): 612-617
2003
ISSN/ISBN: 0017-0011 PMID: 14531339 Document Number: 557730
The aim of the study was to find correlation between the nitric oxide metabolites such nitrite in healthy pregnant women and in intrauterine growth restriction. The decrease of nitric oxide metabolites production may be linked to endothelial cells deficiency. High risk of destruction of biological function of cells by free radical processes is observed in IUGR. It depends on NO deficiency and lipid peroxidation processes. Concentration of NO metabolites measured in pregnancy can show the correlation between oxidative stress and NO metabolism. The study was undertaken in Medical University in Lodz in 2000-2002. The study group consisted of women with IUGR, the control one of healthy women. The group of IUGR was treated with L-arginine-nitric oxide precursor and acetylsalicylic acid. The nitrite activity was measured by Oxis kit, in Grees reaction and was expressed in mumol/l. In group of IUGR low concentration of NO metabolites was observed before treatment. After 20 days of treatment the concentration decreased. In the control group the value was higher than IUGR group/significant difference/and after 20 days of observation decreased as well. We found the difference between the two groups and the decrease of NO metabolite concentration in the course of pregnancy.