Desensitization of H2-like histamine receptors stimulating cyclic AMP formation in the chick cerebral cortex
Sedkowska, P.; Zawilska, J.B.; Nowak, J.Z.
Polish Journal of Pharmacology 55(2): 255-259
2003
ISSN/ISBN: 1230-6002 PMID: 12926556 Document Number: 555607
Histamine potently stimulates cyclic AMP formation in slices of the chick cerebral cortex. Pretreatment of the tissue slices with 10 microM histamine for 2-30 min led to a time-dependent attenuation (when compared with values observed in the control tissue) of the cyclic AMP response produced by subsequent re-stimulation with 1, 10 or 100 microM histamine. The observed histamine-induced desensitization appears to be specific and homologous as the increase in cyclic AMP formation evoked by both forskolin or pituitary adenylate cyclase-activating polypeptide (PACAP) in slices pretreated with 10 microM histamine for 15 min was unchanged. It is concluded that in the chick cerebral cortex, H2-like receptors linked to cyclic AMP-generating system undergo rapid homologous desensitization.