Nutrition and health--unclear association between intake of vitamin E and the risk of coronary heart disease
Buijsse, B.; Feskens, E.J.M.; Kromhout, D.
Nederlands Tijdschrift Voor Geneeskunde 147(41): 2007-2011
2003
ISSN/ISBN: 0028-2162 PMID: 14587142 Document Number: 555546
Vitamin E is a fat-soluble antioxidant and is possibly involved in the prevention of coronary heart disease by inhibiting oxidative modification of LDL cholesterol. The results of studies on the association between vitamin-E intake and coronary heart disease are inconsistent in observational studies and absent in large-scale intervention studies. This may be the consequence of confounding in observational studies and imperfections in the design of intervention trials. Another explanation is that vitamin E may only function protectively in the presence of sufficient co-antioxidants. At present, there is no evidence that vitamin E lowers the risk of coronary heart disease.