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Mutation of GCK gene of Chinese patients with late-onset type 2 diabetes

Liu, Z.; Deng, H.; Tang, W-Li.

Hunan Yi Ke Da Xue Xue Bao 28(2): 99-101

2003

ISSN/ISBN: 1000-5625
PMID: 12934346
Document Number: 555184
Objective To determine the mutation of the Glucokinase (GCK) gene in Chinese patients with Type 2 diabetes. Methods Forty-seven families with Type 2 diabetes were recruited. GCK gene was analyzed by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and direct sequencing. Results Sequence analysis of two abnormal DNA fragments demonstrated a replacement of CfwdarwT at the 38th base in intron 6 and a replacement of CfwdarwT at the 8th base in intron 9, forming two polymorphic sites. Conclusion IVS6 - 38CfwdarwT and IVS9 - 8CfwdarwT were found and mutation of GCK gene may not be a major genetic factor in Chinese patients with Type 2 diabetes.

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