The ability of Candida spp. strains to induce production of tumor necrosis factor and interleukin-6 by whole blood cells

Nawrot, U.; Grzybek-Hryncewicz, K.; Czarny, A.

Acta Microbiologica Polonica 52(1): 87-91

2003


ISSN/ISBN: 0137-1320
PMID: 12916731
Document Number: 554784
The aim of this study was to investigate the ability of C. albicans, C. glabrata [Torulopsis glabrata], C. kefyr, C. krusei and C. parapsilosis to induce production of TNF and IL-6 by whole blood cells of healthy subjects. The highest secretion of TNF and IL-6 was obtained with the 107 and 105/ml heat killed Candida cells, respectively, for all Candida species tested. C. albicans was a better stimulator of TNF and C. glabrata was a better stimulator of IL-6 than other Candida spp. C. krusei was the weakest inductor of IL-6 production.

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