Immunological mechanisms of graft versus tumor effect
Ine, S.; Yamada, M.; Miyamura, K.; Sasaki, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 61(9): 1495-1502
2003
ISSN/ISBN: 0047-1852 PMID: 14515715 Document Number: 554357
Lesson from hematopoietic stem cell transplantation demonstrated that donor immuno-surveillance system can eradicate tumor cells. This is so-call graft versus tumor(GVT) effect. Antigen presenting cells show peptide from minor antigen rather leukemic specific antigen in the context of major histocompatibility complex. The effector cells composed of CD8 T lymphocyte, CD4 T lymphocyte, natural killer cell and natural killer T cell. Death signal was transmitted from effector cells via granzyme/perforin system and FasL/Fas system, and recently TRAIL system seems most important for GVT effect.