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Measurement of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome and its clinical significance

Tang, X.; Yin, C.; Zhang, F.; Fu, Y.; Chen, W.; Chen, Y.; Wang, J.; Jia, W.; Xu, A.

Chinese Medical Journal 116(6): 827-830

2003

ISSN/ISBN: 0366-6999
PMID: 12877788
Document Number: 554309
Objective: To investigate the changes of subgroups of peripheral blood T lymphocytes in patients with severe acute respiratory syndrome (SARS) and its clinical significance. Methods: Subgroups of blood T lymphocytes in 93 patients with SARS were detected by flow cytometer. The results detected in 64 normal subjects and 50 patients with AIDS served as controls. Results: The numbers of CD3+, CD4+, and CD8+ lymphocytes all significantly decreased in acute phase of patients with SARS ((722+-533)/mul, (438+-353)/mul, (307+-217)/mul)) compared with those in normal controls ((1527+-470)/mul, (787+-257)/mul, (633+-280)/mul, all P<0.01)), which was different from what we observed in patients with AIDS who had decreased CD4+ ((296+-298)/mul) but increased CD8+ ((818+-566)/mul) counts. The counts of CD3+, CD4+, and CD8+ lymphocytes decreased more apparently in patients with severe SARS. All the five patients who died had CD4+ counts less than 200/mul. As the patients' condition improved, CD3+, CD4+, and CD8+ counts gradually returned to normal ranges.

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