Molecular pathogenesis of carcinoma of the esophagus
Giménez, A.M.; Copelli, S.B.; Speroni, A.H.; Meiss, R.P.
Medicina 63(3): 237-248
2003
ISSN/ISBN: 0025-7680 PMID: 12876912 Document Number: 554102
Carcinoma of the esophagus is present in two distinct morphological cell types: squamous or pavimentous cell carcinoma and adenocarcinoma. In this article, the main genetic alterations found in both types of carcinomas and their implications are described. The sequence of these alterations is related to histogenesis, making it possible to understand tumor progression from normal epithelium to invasive carcinoma. A comparison is attempted between the molecular development of esophagus carcinomas and that of colorectal carcinoma.