Intralesional therapy of oral leishmaniasis
Czerniski, R.; Gilead, L.; Nasereddin, A.; Abedelmajeed, N.; Markitziu, A.
International Journal of Dermatology 42(9): 752-754
2003
ISSN/ISBN: 0011-9059 PMID: 12956697 Document Number: 553907
In Israel, a 22-year-old man was referred for management of an oral ulcer that had persisted for several days. The patient had also developed an ulceration of the skin on his right thigh some 6 months previously. History showed that he had travelled recently in South America. After histological and molecular examination, a diagnosis of mucocutaneous leishmaniasis was made. Intralesional injections of sodium stibogluconate (Sb) was initiated for the skin lesion, while systemic Sb was indicated for the oral lesion. Although both oral and skin lesions improved, the systemic treatment had to be interrupted because of elevation of hepatic enzymes. When free of systemic therapy, the patient received additional intralesional injections for his oral lesion, which resulted in re-epithelialization and in further healing of the oral lesion. Three weeks later, intravenous Sb was again reinstated for 14 days, and had to be interrupted again due to hepatic enzyme elevation. During the 3-month period of the interrupted systemic treatment, a total of 15 intralesional injections were given until complete healing of the oral lesions was achieved.