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Trial of heparin in viper bites

Paul, V.; Prahlad, K.A.; Earali, J.; Francis, S.; Lewis, F.

Journal of the Association of Physicians of India 51: 163-166

2003

ISSN/ISBN: 0004-5772
PMID: 12725259
Document Number: 553850
Viper bites produce hematotoxicity and coagulopathy which may be either true disseminated intravascular coagulation (DIC) or DIC-like syndrome. Role of heparin is studied in the present study of viper bite cases as use of heparin provides a rational therapy for defibrination caused by viper envenomation. One hundred and twenty two patients with viper bite and incoagulable blood were randomised into test group and control group. Test group received heparin in addition to antisnake venom (ASV). Efficacy was assessed by monitoring bleeding time (BT), clotting time (CT), prothrombin time (PT), platelets, fibrinogen, blood urea (BU), serum creatinine, development of complications and overall outcome. Heparin group showed favourable outcome in all parameters studied. But many of them were not statistically significant. Heparin seems to be having a beneficial role which needs to be confirmed by larger trials and longer duration of heparin administration.

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