Effect of buspirone on aggressive and anxiety behavior of male mice with various aggressive experience
Bondar', N.P.; Kudriavtseva, N.N.
Eksperimental'naia i Klinicheskaia Farmakologiia 66(4): 12-16
2003
ISSN/ISBN: 0869-2092 PMID: 14558344 Document Number: 553757
The effect of the 5-HT1A receptor agonist buspirone on the aggressive and anxious behavior of C57BL/6J male mice with different experience of aggression was studied. In the group of animals with short-time (3 days) winner experience, buspirone (1 mg/kg, i.p.) produced an anxiogenic effect (manifested in the plus-maze test) and reduced the level of aggression (agonist confrontation test). No such effects were observed in the group of animals with a long-time (20 days) aggression experience. It is suggested that the antiaggressive effect of buspirone in the former case is related to the anxiogenic action, while a long experience of aggression reduced the pharmacological sensitivity of 5-HT1A receptors to buspirone in the latter case.