Cerebral ischemic events and anti-cancer therapy
El-Amrani, M.; Aidi, S.; Amarenco, P.
Revue Neurologique (Paris) 159(4): 371-380
2003
ISSN/ISBN: 0035-3787 PMID: 12773866 Document Number: 553545
Antineoplastic agents have been associated with cerebral hemorrhage, infarction and cerebral venous thrombosis. Infarctions have been reported in association with L-asparaginase, cisplatinium, methotrexate and 5-fluro-uracil. The mechanisms by which antineoplastic agents may lead to stroke include endothelium toxicity and abnormalities of coagulation factors.
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