Genetics and congenital heart diseases
Sassolas, F.; Akhavi, A.; Mestrallet, C.; Raboisson, M.J.; Di Filippo, S.; Bozio, A.; Bouvagnet, P.
Archives des Maladies du Coeur et des Vaisseaux 96(11): 1033-1041
2003
ISSN/ISBN: 0003-9683 PMID: 14694778 Document Number: 553496
We describe in this article the recent data on the genetics of congenital heart defects (CHD) organised by type of CHD although each predisposing genetic factor is associated with a whole variety of CHD types. The recent progress resulting from animal models, molecular cytogenetics and CHD familial cases studies allow a better understanding of the determinism of CHD. This lead in term to improved counselling of parents of affected children and of CHD adults who would like to become parents. Nevertheless, more progress is needed to reach a better accuracy in prediction.