Incidence and factors associated with synchronous ovarian and endometrial cancer: a population-based case-control study
AlHilli, M.M.; Dowdy, S.C.; Weaver, A.L.; St Sauver, J.L.; Keeney, G.L.; Mariani, A.; Podratz, K.C.; Bakkum-Gamez, J.N.
Gynecologic Oncology 125(1): 109-113
2012
ISSN/ISBN: 0090-8258 PMID: 22210467 DOI: 10.1016/j.ygyno.2011.12.444Document Number: 551973
To estimate the incidence of synchronous endometrial cancer (EC) and ovarian cancer (OC) in the female population, among all women with EC, and in women under 5 years of age with EC, and to identify factors associated with synchronous EC/OC. All cases of synchronous EC/OC and EC diagnosed in women residing in Olmsted County, Minnesota between 1/1/1945 and 12/31/28 were identified. Incidence was estimated using the population denominator from decennial census data, corrected for hysterectomy prevalence. A case control study using 15 identified cases (EC/OC) and 45 controls (EC alone) was performed. The incidence of synchronous EC/OC and EC (age-adjusted to the 2 US female total and corrected for hysterectomy prevalence) in 1945 28 was .88 and 3.3 per 1, person-years, respectively. Among women under 5 years of age, the corrected incidence of EC/OC and EC was .51 and 5.1 per 1, person-years, respectively. Among all women with EC, 3.1% had a synchronous OC compared to 9.4% of women under 5 years of age with EC. Patients with synchronous EC/OC were more likely than those with EC alone to present with a pelvic mass (57.1% vs. 8.9%, p < .1). Patients with EC alone were more likely to have used oral contraceptive pills (OCPs) than synchronous EC/OC cases (22.7% vs %; Odds ratio, .1; 95% CI, < .1- .87). Although the incidence of synchronous EC/OC in the general population is lower than previously reported, nearly 1 in 1 women diagnosed with EC under 5 years of age will have a synchronous OC.
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