Effect of opioid peptides on the repair regeneration of the bone tissue
Liashev, I.D.
Arkhiv Patologii 64(1): 6-8
2002
ISSN/ISBN: 0004-1955 PMID: 11889706 Document Number: 551706
The study is made of the effects of selective agonists of opioid receptors (DAGO--the agonist of mu-receptors, DSLET--the agonist of delta-receptors, dynorphin A,I-13,--the agonist of kappa-receptors) on reparative osteogenesis in CBA mice. The drugs were injected intraperitoneally within 7 days after bone fracture in equimolar doses: DAGO--6.3 mcg/kg, DSLET--10 mcg/kg, dynorphin A (1-13)--20.2 mcg/kg. It was established that the use of DSLET and DAGO accelerates the development of newly-synthesized spongy bone tissue in the bone regenerate. This manifested with its early appearance (4 days after the fracture) as well as higher indices of specific volumes of bone tissue in the regenerate within the experiment (7, 10, 14 days after bone fracture) in comparison with the control animal group. Dynorphin A(1-13) had no influence on regenerate formation in our experiments.