Significance of nitric oxide function in development of cardiac hypertrophy under condition of experimental renal hypertension
Tishchenko, O.V.; Eliseeva, E.V.; Motavkin, P.A.
Tsitologiia 44(3): 263-269
2002
ISSN/ISBN: 0041-3771 PMID: 12094764 Document Number: 551285
The development of cardiac hypertrophy was studied under condition of experimental renal hypertension on the rat. The number of cardiac nitric oxide synthase (NOS)-positive neurones increased simultaneously with the increase in NOS-activity in these neurones. A connection was found between the development of cardiac hypertrophy and the activity of NOS in cardiomiocytes. The involvement of NO in the development cardiac hypertrophy as auto- and paracrine regulator is supposed.