Metabolic characteristics of immunocompetent cells in children with relapsing herpes
Kurtasova, L.M.; Savchenko, A.A.; Ruzaeva, L.A.; Shmidt, A.R.
Voprosy Virusologii 47(3): 45-48
2002
ISSN/ISBN: 0507-4088 PMID: 12173438 Document Number: 551170
Healthy children aged 1-6 years and patients of the same age with recurrent herpesvirus infection (RHVI) during remission were examined. The levels of NAD(P)-dependent dehydrogenases of blood lymphocytes were measured. Lymphocyte metabolism in the patients was characterized by activation of the key reaction of the pentose phosphate cycle, increased level of the mitochondrial compartment oxidoreductases, increased substrate flow through glucose-3-phosphate dehydrogenase, and inhibition of NADH-dependent dehydrogenase reactions of the cytoplasmatic compartment. A relationship between intracellular metabolism and incidence of RHVI relapses was detected. The metabolic status of blood lymphocytes did not normalize during RHVI remissions.