Prediction of curve progression in idiopathic scoliosis from gene polymorphic analysis
Inoue, M.; Minami, S.; Nakata, Y.; Takaso, M.; Otsuka, Y.; Kitahara, H.; Isobe, K.; Kotani, T.; Maruta, T.; Moriya, H.
Studies in Health Technology and Informatics 91: 90-96
2002
ISSN/ISBN: 0926-9630 PMID: 15457701 Document Number: 550885
Three hundred and four girls with adolescent idiopathic scoliosis were investigated to determine if DNA polymorphisms in the vitamin D receptor (VDR), estrogen receptor (BR), and CYP17 gene were related to curve progression of idiopathic scoliosis. The results suggested that XbaJ site polymorphism in the ER gene was associated with curve progression. The Cobb's curve angle with genotype XX and Xx was statistically greater than that with genotype xx. The curve progression risk (approximately 5 degrees) was higher for genotype XX and Xx than for genotype xx. Furthermore, patients with genotype XX and Xx had a higher risk of receiving operative treatment than those with genotype xx. In conclusion, DNA analysis may predict curve progression, although other polymorphisms were not associated with curve severity.