Role of exocrine cells in pancreatic enhancement using Mn-DPDP-enhanced MR imaging
Gong, J.; Xu, J.; Zhou, K.; Shen, K.
Chinese Medical Journal 115(9): 1363-1366
2002
ISSN/ISBN: 0366-6999 PMID: 12411113 Document Number: 549151
Objective: To investigate role of exocrine cells in the pancreatic enhancement images at Manganese (II) N, N'-dipyridoxylethlenediamine-N, N'-diacetate 5, 5'-bisc (Mn-DPDP)-enhanced magnetic resonance (MR) imaging. Methods: Artificial pancreatic leakage was constructed in six dogs using a fistula tube inserted into the duodenum papillae. Pancreatic juice was collected before and after intravenous infusion of 2 ml/kg of Mn-DPDP at a rate of 2-3 ml/min. The Mn content of pancreatic juice was measured by atomic absorption spectroscopy. T1-weighted spin-echo images and T1-weighted spoiled phase gradient-echo (SPGR) images were obtained prior and approximately 30 min after the administration of Mn-DPDP at 1.5T. Results: The Mn content of pancreatic secretion increased 60.47+-21.83 mug/dl after the administration of Mn-DPDP (t=6.785, P<0.01). The signal/noise ratio (S/N) of the pancreas increased 53%+-49% and 62%+-44% on T1W spin echo images and SPGR images, respectively. Conclusions: Exocrine cells of the pancreas can absorb manganese and excrete it through the pancreatic juice. Exocrine cells play an important role in the enhancement of the pancreas in MR imaging with Mn-DPDP.