Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura
Masset, C.; Dubois, B.; Rorive, G.
Revue Medicale de Liege 57(1): 33-39
2002
ISSN/ISBN: 0370-629X PMID: 11899496 Document Number: 549083
Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies (TMA). Both familial and sporadic forms exist: anaemia, thrombopaenia, renal failure and neurologic disorders are common clinical features. The differential diagnosis depends on plasma levels of von Willebrand factor-cleaving protease: there is a deficiency of this protease in patients with TTP whereas its rate is normal in HUS. We remind pathophysiology, etiologies and treatment of these TMA.