A patient with diffuse peritoneal metastases of GIST who was administered STI571
Mukaide, H.; Hasuike, Y.; Takeda, Y.; Shin, E.; Mishima, H.; Nishisyou, I.; Tujinaka, T.; Kawahara, K.; Kurata, A.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 29(12): 2329-2332
2002
ISSN/ISBN: 0385-0684 PMID: 12484066 Document Number: 548425
We report a patient with diffuse peritoneal metastases of GIST who was administered STI571 (a tyrosine kinase inhibitor). She was a 45-year-old woman who underwent surgery for a mass that was suspected to be an ovarian tumor. The postoperative diagnosis was GIST developing from the small intestine. Two years later, multiple peritoneal metastases were noted and a complete macroscopic resection was done. Six months after the second operation, she needed a third operation and complete macroscopic resection was repeated. Only 4 months after the third operation, she underwent a fourth operation. We resected massive peritoneal metastases, but diffuse metastases remained. Therefore, we started to administer STI571 at 400 mg/day. She has been free from peritoneal masses for 9 months after the fourth operation. We recommend STI571 for uncontrolled diffuse peritoneal metastases of GIST.