Transplantation surgery and immunology: from origins to new paradigms of immune tolerance
Reding, R.
Bulletin et Memoires de l'Academie Royale de Medecine de Belgique 157(10-12) 439-444; Discussion: 444-447
2002
ISSN/ISBN: 0377-8231 PMID: 12854184 Document Number: 548300
The technique of vascular anastomosis (A. Carrel, 1902) and the developments of transplantation immunology, allowed the first successful attempts at clinical organ grafting in the early sixties. The introduction of new immunosuppressors and surgical techniques both contributed to the introduction of organ transplantation into daily practice. Preclinical and clinical research on immunologic tolerance offers the perspective of immunosuppression withdrawal and of full rehabilitation after transplantation.