Neonatal lupus erythematosus with recurrent pancytopenia: a case report
Wang, L-Jen.; Yang, Y-Hsu.; Lin, M-I.; Chiang, B-Luen.; Mu, S-Chi.
Journal of Microbiology Immunology and Infection 35(4): 262-264
2002
ISSN/ISBN: 1684-1182 PMID: 12542254 Document Number: 547946
Neonatal lupus erythematosus is an immune-mediated disease associated with the transplacental passage of maternal autoantibodies, primarily anti-Ro (SS-A) and anti-La (SS-B). The major clinical manifestations are isolated congenital heart block and cutaneous lupus lesions. Other symptoms include hematologic and hepatic abnormalities. We report a male neonate, born to a mother with Sjögren's syndrome, who experienced cutaneous lupus lesions and 2 episodes of pancytopenia. Both anti-Ro and anti-La antibodies were positive in infant and mother.