Tumour morphology and radiotherapy immediate response in laryngeal tumours
Monteiro, E.; Varzim, G.; Lopes, C.; Ferreira, E.
Anales Otorrinolaringologicos Ibero-Americanos 29(6): 559-571
2002
ISSN/ISBN: 0303-8874 PMID: 12596349 Document Number: 547896
Laryngeal cancer is relatively frequent in South Europe countries and its incidence suffered variations in last decades. Treatment options are usually based on histology, T category and stage. Tumors unchain in neighbour tissues the presence of cells that normally are associated to inflammatory response. A possible association between tumour inflammatory response and radiotherapy efficacy is focused in occasional papers. Several histological parameters (histologic type, nuclear grade, desmoplasia, necrosis, and cells normally involved in inflammatory response) were analysed in biopsy material obtained from 67 patients with laryngeal cancer treated with primary radiotherapy in our department. Statistical analyses were made in order to assess a possible association between tumour morphology and radiotherapy response.