Severe opiate withdrawal in a heroin user precipitated by a massive buprenorphine dose
Clark, N.C.; Lintzeris, N.; Muhleisen, P.J.
Medical Journal of Australia 176(4): 166-167
2002
ISSN/ISBN: 0025-729X PMID: 11913917 Document Number: 547322
By diverting his dispensed medication, our patient collected 11 buprenorphine tablets (8 mg each), which he took in one day. The result was not respiratory depression, but instead severe opiate withdrawal lasting four days - this scenario has not previously been reported. This case highlights features of the unique pharmacology of buprenorphine and some key issues for its use in the management of heroin dependence.