Crystallochemistry of copper (II) and zinc (II) chelates by nonsteroidal antiinflammatory drugs
Viossat, B.; Morgant, G.; Sorenson, J.R.J.; Roch-Arveiller, M.; Daran, J.C.; Greenaway, F.T.; Nguyen Huy, D.
Annales Pharmaceutiques Francaises 60(2): 102-114
2002
ISSN/ISBN: 0003-4509 PMID: 11976555 Document Number: 547015
Copper(II) and zinc(II) chelates by some non-steroidal antiinflammatory drugs NSAIDs (niflumic acid, indomethacin) and 3,5-diisopropylsalicylic acid (DIPS) were characterized by single X-ray diffraction methods. Copper(II) complexes by these two types of chelates are binuclear compounds, with Cu(2)(DIPS)(4)L(2) or Cu(2)(AINS)(4)L(2) formula (L=axial non-NSAID ligand such as diethylether, dimethylsulfoxide DMSO). In zinc(II) complex by DIPS, the metal ion is tetrahedrally coordinated and the corresponding compound is mononuclear with Zn(DIPS)(2)(DMSO)(2) formula. These copper(II) and zinc(II) complexes were found to be more active than their parent drugs from the antiinflammatory and anticonvulsant properties. It was pointed out that the Cu(2)(DIPS)(4)L(2) complexes (L=diethylether, N,N-dimethylformamide) exhibited no rotorod toxicity when examined for anticonvulsant activity using the seizure produced by maximal electroshock, following oral administration to rats.