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Levels of autoantibodies to glutamate receptors and immunological blood parameters in patients with epilepsy

Bazarova, V.G.; Granstrem, O.K.; Dambinova, S.A.

Voprosy Meditsinskoi Khimii 48(4): 381-387

2002

ISSN/ISBN: 0042-8809
PMID: 12506615
Document Number: 546788
The role of glutamate receptors in the brain spiking activity was evaluated. The electroencephalographic (EEG) spiking activity was monitored and autoreactive antibodies (aAbs) to subunits of glutamate receptors were assessed in the blood serum of epileptic and ischemic stroke patients. We showed that the level of GluR autoantibodies in blood serum of patients correlates to the intensity of the brain paroxysmal activity. These data confirm our previous observations. The level of GluR1 aABs has been proposed as a specific biomarker typical for epilepsy. This approach could be recommended as an additional criterion for diagnostic of nervous diseases such as epilepsy and ischemic stroke.

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