Vascular endothelial growth factor--fundamental research and experimental study in plastic surgery
Huang, C.-y.; Shen, Z.-y.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 16(1): 64-69
2002
ISSN/ISBN: 1002-1892 PMID: 11826659 Document Number: 546623
To review the fundamental research and the experimental study of vascular endothelial growth factor (VEGF). The laboratory information and experimental study of VEGF were extensively reviewed. VEGF, as a mitogen specifically for endothelial cells, could strongly stimulate angiogenesis as well as vascular permeability, especially in hypoxia state. Experimentally, survival area and viability of flaps could be increased significantly when exogenous VEGF was applied in the form of protein or cDNA. VEGF provides a new way for therapeutic angiogenesis in reparative and reconstructive surgery.
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